URGENT ACTION NEEDED
Animal Experimenters Want To Shut Us Up
Pro-animal research bullies want to see
Multi-Billion Dollar Lie fail. They have
given it more
dislikes than
any
Kinship Circle movie ever made! If you care about animals, medical advancement, and
cures for humans — please do these 3 actions ASAP:
- WATCH MOVIE so it gets more views and
shows in YouTube searches, menus.
- LIKE THE MOVIE by clicking the thumbs-
up symbol on YouTube.
- POST POSITIVE COMMENTS to boost
popularity and views.
Be A Sound-Bite For Animal-Free Research
- SPEECH & LANGUAGE: Speak intelligently, not emotionally, on animal
research flaws and development of superior non-animal
tools.
- GET HARD FACTS: Pro-animal research wants to intimidate you. Know
industry facts.
FILM SCRIPT: Click
here to read
and copy text from film
FACT SHEET: Click here
to download Animal
Experimentation facts
- ACTION ALERTS: Join Kinship Circle or any group that does animal research
alerts.
- LIVE CRUELTY-FREE: Only buy consumer products not tested on animals. While
this won’t apply to drugs, it will cover household
good, makeup and personal care.
FILM SCRIPT
The Multi-Billion Dollar Lie: Animal
Experimentation
Be The Sound-Bite That Roars, In An Apathetic World
Overwhelmed by the complex "problems we face today."
In polls from CBS News, Pew Research, CNN, ABC, Washington Post, Reuters, New York
Times, USA Today, Gallup…
ISSUES THAT MATTER TO PEOPLE MOST:
Economy/Jobs - 50%
Budget Deficit/National Debt - 7%
Health Care - 5%
Immigration - 2%
Education - 2%
War/Peace - 2%
Politicians/Government - 2%
Partisan Politics - 2%
Misc. Social Issues - 2%
Other - 21%
How do you get people to care? About a topic that is not part of any mainstream
discussion?
Making the best case for animal-free research: In everyday conversation,
letters, action alerts, articles, ads, billboards,
literature…
To show human-focused research = medical progress for people.
FRAME ANIMAL RESEARCH AS A POLITICAL ISSUE
The animal research industry reflects basic tenets of a
political issue:
- NEUTRAL ISSUES
Government regulated areas and their impact on society:
- Food & Drug Safety
- Biotechnology
- Environmental Protection, etc.
- PARTISAN ISSUES
Behavior driven by self-serving objectives:
- Mega-Profit Pharmaceutical Industry
- Grant-Driven Medical Research
- Quick-To-Market Consumer Products
- CORRUPTION
Issues that resort to legislative or commercial powers for private gain that HARMS
the greater society for which they exist.
ANIMAL RESEARCH IS A MULTI-BILLION DOLLAR BUSINESS
- IN 2012: Brand drugs will earn $156.3 billion. Generic drugs will make $52.8
billion.
- National Institutes of Health will spend some $12-18 billion taxpayer dollars on
redundant animal experiments at medical universities
seeking grants.
- 47 of 53 landmark animal findings cannot even be reproduced. "It was
shocking. Pharmaceutical industry relies on these studies
for drug development." Failure is
blamed on use of animal models, irrelevant to cancers or other disease, in an
academic setting that fosters poor science, even fraud, as
researchers compete for funding. "Too
many discoveries done in animals are wrong." C. Glenn Begley, former head of
global cancer research at Amgen. Journal: Nature, Mar
2012.
PHARMACEUTICAL SALES & LOBBY:
- Drug reps hard-sell doctors with gifts and biased data.
- They lobby doctors/politicians more than any USA industry.
- Doctors prescribe hyped drugs, even if not best remedy.
EVERY DRUG SOLD IS ANIMAL-TESTED. THAT’S THE LAW.
1734 drugs have been recalled in recent years
SAMPLING OF RECALLED DRUGS PROVEN "SAFE" IN ANIMAL TESTS
FIALURINE: Safe in dogs tests. Causes liver
failure in 7 of 15 hepatitis patients.
ZELNORM: Animal-tested gastrointestinal drug. Chance for heart attack or
stroke in humans.
HEPARIN (blood thinner): Recalled after 400+ allergic reactions and 19 human
deaths.
MILRINONE: Ups survival rate for rats with induced heart failure. In humans, a
30% rise in mortality.
NOMIFENSINE: Nontoxic in rats, rabbits, dogs, monkeys. In humans: liver
poisoning, anemia.
ZOMAX (painkiller): Tests safe in animals. 14 humans die. Side effects in
more.
STREPTOMYCIN (antibiotic): Tests safe in pigs, dogs, guinea pigs. Causes brain
damage, deafness, blindness or death in
human babies.
ARAVA: Tests safe in animals. Tied to 22 human deaths in rheumatoid arthritis
users.
VIOXX, CELEBRAX, BEXTRA: Up heart disease risk in humans, despite years of
animal testing.
PREMARIN, PREMPRO: HRT from pregnant-mare urine ups risk for coronary heart
disease, breast cancer, stroke, pulmonary
embolism, endometrial cancer, colorectal cancer, hip fracture, death.
BAYCOL, MERIDIA, SERZONE, FENPHEN: Pulled or restricted after animal testers
approved them.
AMRINONE: Shows promise in mice, rats, hamsters, guinea pigs, dogs, rhesus
monkeys. The cardiac drug kills some people.
ISUPREL: Dosing derived from animal tests. 3,500 asthmatics in Great Britain
die.
ETC… All these drugs tested safe for people in animal experiments.
ADVERSE DRUG REACTIONS (ADRs)
- 4th leading cause of death in the USA
- Approved drugs harm 2 million people a year.
- At least 100,000 die.
Journal of the American Medical Association
9 of 10 experimental drugs fail in clinical studies because we can't accurately
predict how they'll behave in people based on animal
studies.
Mike Leavitt, former U.S. Health & Human Services Secretary
ANIMAL RESEARCH IS A:
- Human rights issue
- Patient rights issue
- Taxpayer rights issue
It ought to matter to people who care about:
- Government overspending
- Corporate corruption
- Health/safety for themselves, their children
Where is public outcry over research fraud, like the outcry over tobacco industry
fraud? WARNING: Animal research may cause adverse drug
reaction,
disability or death in humans.
VOICEOVER:
When I think about what goes on under the radar inside research labs, I just feel so
angry, so sad. And if I can just get even ONE more person
to see what I see, know what I know. And then that one person becomes another, and
another and another, until we are the
majority who try to expose one of the most corrupt industries of all.
But I also realize the animal research industry is a form of ACCEPTED CRUELTY. A
sort of SACRED COW that society believes must occur for
the greater good. For example, we must experiment on animals to find cures for
cancer, AIDS and other human disease. To save
children. And to advance medical science.
But that’s not even true. And all the data to confirm the failure of the
animal model is right there, in quotes from the research
industry itself — which is the only we should look to argue on behalf of animal-
free research methods.
There is no animal experiment that can confirm safety for human use of drugs,
vaccines or other compounds. Because no animal can produce
clinical symptoms — or even metabolize a drug in the same way — that are
relevant to human disease, wounds or trauma. All
animal experiments mislead researchers with false conclusions that can ultimately
hurt people.
END VOICEOVER
- MISLEADING: The animal model presumes a harmful effect in one species will
occur in another. Science itself accepts that
genetic, metabolic, biochemical, anatomic, physiological and psychological traits
vary significantly between species.
A drug interacts differently with various body functions from species to species. By
the time a pig, dog or mouse digests a drug it doesn't look
anything like the same drug in a person. (image: a drug encounters a living cell)
- ANIMAL TESTS DON'T MIMIC HUMAN EXPERIENCE: Injury or disease artificially
created inside a lab fails to produce real-life
symptoms relevant to humans. (image: a monkey is manipulated for head trauma
experiments at University of Pennsylvania)
- EXPERIMENTERS DRAW FALSE CONCLUSIONS: Stress itself — from handling,
restraint, pain, injury — is a deceptive
variable shown to obscure data. Contemporary Topics in Laboratory Animal
Science
INSANITY. Animal research seems beyond criticism, rarely exposed in news,
TV or film.
ANIMAL-FREE RESEARCH TECHNOLOGY CAN HEAL
HUMANS
"I am pro-medical research. That’s why I want my tax dollars to support studies
that lead to cures."
ANIMAL-FREE RESEARCH TOOLS
Biotechnology breakthroughs: Cell-tissue analysis using elements from building blocks
of active human cells.
SCIENCE WITH HUMAN-RELATED RESULTS:
- In vitro cell/tissue culture analysis
- 3D tissue formations of human organs
- Bioinformatics, computer analysis of biological data
- Proteomics, gene proteins
- Metabonomics, human metabolic response to drugs, environment, disease
- Systems biology and in silico (computer-based)
- Epidemiology, clinical research and post-market surveillance of drugs
- Autopsy/biopsy studies
- Magnetic imaging, CAT, PET, MRI scans
- Pharmacogenetic studies with DNA chips; Videos & mathematical modeling
- Human-like simulators such as TraumaMan System for surgery/trauma training
CONSUMER PRODUCT SAFETY TESTS / ANIMAL TESTING IS NOT REQUIRED FOR:
- beauty/personal care items
- household/cleaning items
- non-drug items
Most companies still use it, despite alternatives.
SAMPLING OF NON-ANIMAL TOXICITY TESTS VALIDATED
OR UNDER ASSESSMENT �
HIGH-THROUGHPUT ASSAYS:
Hundreds human cells go into thousands of tiny wells in a glass tray. A computerized
device drips a different chemical into each well and
measures remaining cells to assess toxicity.
FOR SKIN SENSITIZATION TESTING:
- Cell-Based Tests / hCLAT, Human Cell Line Activation Test
- MUSST, Myeloid U937 Skin Sensitization Test
- DPRA, Direct Peptide Reactivity Assay
- Local Lymph Node Assay (rLLNA)
FOR SKIN IRRITATION TESTING:
- EpiSkin
- Modified EpiDerm SIT
- SkinEthic RHE / Cultured human tissue equivalents
- Epipack Test / Cloned human cells assess skin irritants
- 3T3 Neutral Red Uptake Phototoxicity Test (3T3 NRU PT) / Measures chemical
toxicity under ultraviolet
radiation
FOR SKIN CORROSION TESTING:
- EST-1000 RHE / Reconstructed human epidermis
- Corrositex Assay / Artificial skin tests chemical burn potential
FOR EYE IRRITATION TESTING:
- Cytosensor Microphysiometer and Fluorescein Leakage Assays
- SkinEthic RCE (peptide binding and GSH) and EpiOcular / Human reconstituted
tissue models, EpiOcular
is alternate cornea made from manufactured tissue
- Organotypic Assays (BCOP, ICE) / For non to mild irritants
- Irritection Assay; Neutral Red Bioassay
- Transepithelial Passage Assay
- Agarose Diffusion Method / Human cells with test matter in container, test
material is toxic if dead cells cluster
around it.
FOR ACUTE HUMAN TOXICITY:
- In Vitro Cytotoxicity (MEIC) / Predicts poison in chemicals
- In Vitro Pyrogen / Assesses drug fever/inflammation properties in human donor
blood
FOR GENOTOXICITY TESTING:
- In Vitro Micronucleus (MNvit) Assay / To detect chemicals inducing chromosome
breakage
(clastogens) or changes in chromosomal numbers (aneugens)
- Micronucleus and Comet Assays / In reconstituted 3D human skin models
FOR CARCINOGENICITY TESTING:
- Two Cell Transformation Assays (CTA)
- Based on SHE and Balb/c 3T3 cells
- Cell Transformation Assay / Using Bhras cells
FOR REPRODUCTIVE TOXICITY/ENDOCRINE DISRUPTORS:
- PANVERA Estrogen Receptor Binding Test
- STTA Assay Reproductive
- HeLa Estrogen Receptor Antagonist Assay
- VITO/B Anti-Estrogenic Compounds
- BAYER/D
- MELN / MCF-7 human breast cancer cells
- LUMI-CELL Estrogen Receptor Transcriptional Activation Assay
FOR ACUTE ORAL SYSTEMIC TOXICITY TESTS:
- Balb 3T3/NRU Cytotoxicity Assay
- Human HepaRG CYP induction test method
- Human Cryohep CYP induction test
If we care, we must give animal research listening power, by framing it
as a:
- HUMAN RIGHTS ISSUE
- PATIENT RIGHTS ISSUE
- CONSUMER RIGHTS ISSUE
- TAXPAYER RIGHTS ISSUE
- HEALTH/SAFETY CONCERN FOR ALL
KINSHIP CIRCLE ANIMAL EXPERIMENTATION LITERATURE: Animal Experiments, Get Facts
A broken model, inspired by profit.
Animal cruelty?
This film has not used these words until now. Because cruelty is inherent.
Cruelty is the very nature of animal experimentation.
"Animal experiments offer the illusion of control. We create false data which,
combined with differences in species, make our efforts
to apply results to man, useless." Dr. Roger E. Ulrich
SUPPORT ANIMAL-FREE RESEARCH. SUPPORT LIFE.
